Synthesis and Antibacterial Activityof2-Phenyl-3-Substituted Phenyl-5-Arylidine-4-Oxo-Thiazolidines

Anjani Solankee; Pankaj Mistry; V. M. Patel

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Synthesis and Antibacterial Activityof2-Phenyl-3-Substituted Phenyl-5-Arylidine-4-Oxo-Thiazolidines

Anjani Solankee, Pankaj Mistry and V. M. Patel

Department of Chemistry, B K M. Science College. Valsad 396 001 (India)

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ABSTRACT:

Addition of thioglycolic acid to Schiff-bases, resulted in the formation of 4-thiazolidinones. Addition of 3,4,5-trimethoxy benzaldehyde to 4-thiazolidinones resulted in benzylidene derivatives of 4-thiazolidinone. The synthesised compounds were characterised on the basis of elemental analysis and spectral studies and tested in vitro against E coii, S. aureus, S. typhi and E. aerogenes for their antibacterial activity.

KEYWORDS:

Activityof2-Phenyl-3-Substituted; Phenyl-5-Arylidine-4-Oxo-Thiazolidines