Abstract
Copper (I) iodide nanoparticles on polyaniline as a green, recoverable and reusable catalyst for multicomponent click synthesis of 1,4-disubstituted-1H-1,2,3-triazoles
Shervin Saadat1*, Simin Nazari2, Mozhgan Afshari3, Maryam Shahabi4, Mosadegh Keshavarz4*
DOI : http://dx.doi.org/10.13005/ojc/310248
Abstract:
A one-pot procedure for the synthesis of 1,4-disubstituted-1H-1,2,3-triazole derivatives via the three component coupling reaction between terminal alkynes, benzyl halides/α-halo ketones and sodium azide in the presences of CuI nanoparticles supported onto polyaniline (Nano CuI/PANI) catalyst in water has been developed. This heterogeneous catalyst showed high catalytic activity and 1,4-regioselectivity for click cyclization in water as a “green” solvent and good to excellent yields were obtained in all cases over repeated five runs.
Keywords:Nanoparticles; Click chemistry; Heterogeneous catalyst; Benzyl halide; α-halo ketones; Triazole
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