Abstract

S. Uthayanila¹ , P. Neeraja²

DOI : http://dx.doi.org/10.13005/ojc/310229

Ruthenium possesses several favorable properties suited to rational anticancer drug design when conjugation with the  porphyrin moiety was accomplished through peripheral pyridyl rings. The ruthenium porphyrin conjugates are soluble at least moderately in aqueous solution and are thus suitable for biological investigations in particular for cytotoxicity and photocyotoxicity tests. In present study the compound 5,10,15,20 tetra pyridyl porphyrin coordinated to four [Ru (bipy)₂ Cl]+ groups (meso-5,10,15,20 tetrakis {4(chloro-bis-bipyridyl ruthenium(II)) pyridyl} porphyrin) is synthesized by modified Alder method. This compound is characterized by UV-Visible Spectroscopy, FT-IR Spectroscopy, ¹H-NMR spectroscopy, Fluorescence Spectroscopy and Cyclic Voltametry. In-Vitro anticancer activity of the compounds have been evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay method. The results show that the compound is cytotoxic against human lymphoma cancer cells.

Cytotoxic; FT-IR; Cyclic Voltametry; Fluorescence; UV-Visible; NMR

[ View HTML Full Text]