Abstract

S. Sindhu*, Seena Thomachan and V D  John

DOI : http://dx.doi.org/10.13005/ojc/310245

The present investigation includes the synthesis, characterization, antitumour and antimicrobial activities of three new curcuminoid analogues and their metal chelates. Curcuminoid analogues and their metal chelates have great ability to act as antitumour and antimicrobial agents which motivated us and lead to this present work.  The  new curcuminoid analogues namely 1,7-di(1-naphthyl)-1,6-heptadiene-3,5-dione (1a), 1,7-di(2-methoxy 1-naphthyl)-1,6-heptadiene-3,5-dione (1b), 1,7-di(2-hydroxy 1-naphthyl)-1,6 -heptadiene-3,5-dione and their Cu(II) and Al(III) complexes were synthesized and characterized using UV, IR,¹HNMR and Mass spectral data. The curcuminoid analogues and their metal complexes were studied for their cytotoxicity and antibacterial ability using Trypan blue exclusion method and agar well diffusion method respectively. The present study suggests that the Cu(II) complexs   showed remarkable enhancement of cytotoxic activity where as the Al(III) complexs were found to be most active towards antimicrobial activity.

1; 7–dinaphthyl heptanoids; NMR; mass spectra; cytotoxicity; antimicrobial activity

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