ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Bis(2-cyanoacetamide) in Heterocyclic Synthesis: Synthesis of Some Bis[2-oxopyridine, 2-iminochromene, Chromeno[3,4-c]pyridine, Benzochromeno[3,4-c]pyridine] Derivatives

H. Kh. Thabet1*, Mohd Imran2, Saleh Alaql2, M. H. M. Helal1

DOI : http://dx.doi.org/10.13005/ojc/400108


Abstract:

N,N'-(methylenebis(1,4-phenylene))bis-(2-cyanoacetamide) was exploited as a precursor for synthesing some bis (benzylidene 5a-c, pyridines 7, 8, 10a,b, chromene 14, benzochromene 15) derivatives containing diphenyl-methylene spacer via the reaction with each of aromatic aldehydes, pentane-2,4-dione, acetaldehyde/ malononitrile, arylidene-malononitriles, ethyl cinnamates, 2-hydroxybenzaldehyde, and 2-hydroxy-1-naphthaldehyde). Bis(chromeno[3,4-c]pyridines 16&18) were synthesized via Michael's addition of malononitrile or ethyl cyanoacetate to bis(chromene) derivative. The newly prepared compound structures were established via ir, NMR spectroscopic data.

Keywords:

Bis[2-cyanoacetamide; chromeno[3,4-c]pyridines]; 2-cyanoacrylamides; 2-imino-chromenes; 2-pyridones

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