Abstract
Rational Design, Synthesis, Characterization, and Anti-Bacterial Activity of Urea Derivatives Bearing 1,2,4-Triazoles as Molecular Hybrid Scaffolds
Sunil Kumar Choudhary1, Priya Gothwal1, Nidhi Sogani2, Ajay Saini3 and Suman Swami4*
DOI : http://dx.doi.org/10.13005/ojc/390115
Abstract:
A new set of molecular hybrids, urea derivatives carrying 1,2,4-triazole as molecular hybrid scaffolds, were developed, synthesised, characterised, and assessed for potential anti-bacterial action. Triazole scaffolds are key moieties in many pharmacological compounds, and their inclusion with urea moiety makes them more valuable for biological purposes. As a result, urea derivatives containing 1H-1,2,4-triazole and 3-(methylthio)-1H-1,2,4-triazole moieties were produced by reacting carbamates of 4-amino-1,2,4-triazoles and 3-(methylthio)-4-amino-1,2,4-triazole with amines in DMF using trimethyl amine for 15 hours at ca. 60°C. 1H NMR, 13C NMR, FTIR, and HRMS techniques were used to characterise all of the produced compounds. The anti-bacterial activity of all produced derivatives was examined against Enterococcus faecalis, Pseudomonas, E. Coli, Klebsiella pneumonia, Candida albicans, Bacillus anthracis, Proteus mirabilis, and Staphylococcus aureus.
Keywords:Anti-Bacterial Activity; 4H-1,2,4-triazol-4-amine; 3-(methylthio)-4H-1,2,4-triazol-4-amine; molecular hybrid scaffold; Urea
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