Abstract

G. Sankar^*

DOI : http://dx.doi.org/10.13005/ojc/390102

A Bistable RNA pairs have noteworthy importance in RNA ribo-switches, RNA thermometers and viroid replications, making this molecule particularly interesting to chemists and scientists working in field of biochemistry, virologists and computational chemistry. It adopts equilibrium between two distinct hairpin conformations. The two hairpin conformations adopt different functionality. In this review paper, we discuss the pathways used by bistable RNAs for switching confirmations and look into the future possibilities existing mechanisms can yield in RNA and retro-virus RNA studies.

Bistable RNA; Base-pair-exchange pathway; mutated RNA; 34-mer RNA; pseudo knot pathway; RNA dance pathway; Unfolding- Refolding pathway

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