Abstract

Vilas Sudrik^1*, Arjun Bodkhe² ,Dnyaneshwar Karpe¹ and Shamrao Lawande¹

DOI : http://dx.doi.org/10.13005/ojc/380611

A facile one-pot synthesis of Stiripentol (STP) 1 in which Initially 3, 4-dihydroxy benzaldehyde 13 is treated with methylene diiodide using base KOH to get 2 which undergoes in situ Knoevenagel condensation with 3,3-dimethyl 2-butanone using catalytic Phase Transfer Catalyst i.e. Tetrabutylammonium bromide (TBAB) and K2CO3 to get 4 which undergo Regioselective Luche reduction of α-β unsaturated ketone with NaBH4 and Cerium (III) chloride (CeCl3) to get pure Stiripentol 1 which is commercially viable and eco-friendly.

Antiepileptic; Commercially Feasible; 4 dihydroxy benzaldehyde; Knoevenagel Condensation; Regioselective Luche reduction; Tetrabutyl ammonium bromide

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