Abstract

Arjun Bodkhe^*, Vilas Sudrik, Dnyaneshwar Karpe and Shamrao Lawande

DOI : http://dx.doi.org/10.13005/ojc/380631

Novel one-pot process for the preparation of tolcapone., 2-methoxy anisole compound 9 treated with 4-methyl benzoyl chloride compound 10 using aluminium chloride gives 4-hydroxy -3-methoxy-4-methyl benzophenone compound 11 Further on nitration using new nitrating agent i.e. melamine nitrate to get corresponding nitro benzophenone compound 6. After demethylation using 48% HBr-Acetic acid to get pure Tolcapone 1 by the cost-effective and commercially feasible process.

Industrially Feasible; Melamine nitrate; One-pot process; Parkinson's disease; Tolcapone

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