Abstract

Vimaladevi Krishnasamy ^*, Selladurai Madhiyan, Poonkodi Kathirvel, Prabhu Velliangiri, Mini Raman and Abinaya Anandhan

DOI : http://dx.doi.org/10.13005/ojc/380614

In this invistigation, we assessed the composition of the essential oil from the leaves of Artabortrys hexapetalus (L.f.) Bhandari, in vitro antioxidant and anticancer activities. The hydrodistilled essential oil from A. hexapetalus leaves cultivated in the southern Western Ghats was evaluated by GC/MS for its chemical composition. 34 compounds were present, according to the results of GC/MS analysis. The predominant constituents include Caryophyllene (17.2%), Copaene (12.9%), α-Bisabolene (8.3%), Biocyclogermacrene (6.3%), α-Cadinol (6.2%), β-Myrcene (5.7%), δ- 3-Carene (5.3%), and γ-Muurolene (4.9 %). The minor constituents are Gurjunene (3.5%), Longipinane (3.5%), Patchoulene (3.1%), Trans cadinal (2.8%), Ledol (1.4%), α-Phellandrene (1.3%), and Patchouli alcohol (1.3%). The DPPH and ABTS assays were used to measure the antioxidant activity of the A. hexapetalus essential oil, with ascorbic acid as a reference. The essential oil demonstrated antioxidant activity by having IC50 values of 104 and 122 µl/mL, respectively. Further the essential oil has tested its in vitro anticancer potential using the MTT assay on the HeLa cancer cell line and showed significant anticancer activity with an IC50 value of 36.7 µg/mL.

Artabortrys hexapetalus; ABTS; DPPH; GC/MS; HeLa cell line; MTT

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