Abstract

Selvaraj Jayanthi¹, Thangarajan Sugumaran², Periyasamy Monisha¹, Kittappa Gunasundari¹, Moorthy Vetriselvan¹, Manickam Pramesh¹ and Ragunathan Venkatachalam^1*

DOI : http://dx.doi.org/10.13005/ojc/380510

A catalyst-free synthetic strategy to chromene carbonitriles by Multi-Component Reaction of pyrazole aldehydes, 5,5-dimethylcyclohexane-1,3-dione and malononitrile with ethanol, at room temperature is reported. Screening of solvents and purification of the compounds were also performed. The newly synthesized novel compound’s (4H-chromene-3-carbonitriles) structures were authenticated by the spectral techniques viz. (1H , 13C)Nuclear Magnetic Resonance, FT-IR, and LC-MS analysis.

4H-chromene-3-carbonitrile; Catalyst-free; Ethanol; E.A – Ethyl Acetate; Multicomponent; Multi-Drug Resistant-MDR; P.E- Petroleum Ether; RT- Room Temperature; TMS-Tetra Methyl Silane

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