Abstract

Priyanka Yadav^1*, Arun K Mishra² and Harpreet Singh³

DOI : http://dx.doi.org/10.13005/ojc/380504

Bryophyllum pinnatum Lam. (Oken) (Crassulaceae) are commonly known as miracle plant. Traditionally, this plant is used to heal wounds and to treat diarrhoea. For this reason, the main aim of the present study is to evaluate the antidiarrheal activity using castor oil-induced diarrhea model. Loperamide drug (3 mg dose,) was used as standard drug. The EAE and EE at 200mg dose and 400 mg dose, respectively produced dose-dependent protection of mice with significant P value. Both extracts of plant produced dose-dependent and significant P-value towards antimotility effect compared with negative control (castor oil) group in model. EE (400 mg dose) possess better antidiarrheal potential in mice groups due to presence of flavone. 5-methyl-4,5,7- trihydroxy flavone was isolated from the ethanol extract. Finally, it can be concluded that, Bryophyllum pinnatum Lam. (Oken) leaves can be used ethnomedicinally to treat, counterbalance, bulwark, and control diarrhea.

Antidiarrheal activity; Bryophyllum pinnatum Lam.(Oken); Ethanol extract; Ethyl acetate extract

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