Abstract

Prajakta Shamrao Sadavarte, Bhaskar Hari Zaware* and Sushama Jayawant Takate

DOI : http://dx.doi.org/10.13005/ojc/380427

The current approach involves the kinetic investigation of Thiobenzamide (TB) and cyclohexanone thiosemicarbazone (CTSC) in solution with 3-chloroacetylacetone(3-CAA). The study revealed a second-order rate constant with respect to both reactants, thioamide and an α-halo carbonyl compound. The energy of activation (Ea) was found to be Ea 48.8176 kJ/mol/K for thiobenzamide and 33.08692157 kJ/mol/K for Cyclohexanone thiosemicarbazone. The salt effect study showed the formation of ionic species during the reaction. The reactions were studied with respect to changes in dielectric constant using solvent systems like water-ethanol and water-isopropanol.

Cyclisation; Dielectric Constant; Kinetics; Mechanism; Thermodynamic parameter

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