Abstract

Alifa Husnun Kholieqoh^1*, Tengku Sifzizul Tengku Muhammad^1,2, Habsah Mohamad¹, Hazem Choukaife³, Salma Seyam³, Mulham Alfatama³ and Yosie Andriani¹

DOI : http://dx.doi.org/10.13005/ojc/380404

Excess reactive oxygen species can cause oxidative stress and lead to the progression of cardiovascular diseases. Pandanus tectorius fruit (PTF) is a promising source of herbal medicine with antioxidant activity. However, the oral administration is hindered due to the semi-polar properties of the extract. The solubility of the extract can be potentially improved through synthesis of a self-nanoemulsifying drug delivery system (SNEDDS). This study aims to formulate nanoemulsion of the extract by means of self-nanoemulsification approach using caprylic triglycerides, kolliphor RH40, and propylene glycol. It was found that when tested in water, simulated gastric, and intestinal fluid, PTF-SNEDDS had emulsification times of 38.17, 49.44, and 45.29 sec, indicating grade A formulation. The clarity level of PTF-SNEDDS, particle size, and zeta potential was at 99.3%, 41.5 ± 1.1 nm, and -25.9 mV. The antioxidant activity of PTF-SNEDDS was 1.6 times higher than PTF extracts. It can be concluded that PTF extract can be formulated into SNEDDS and stable in gastrointestinal conditions.

Antioxidant; Oral Bioavailability; Pandanus tectorius; SNEDDS

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