Abstract

Nilesh Vishnu Junghare¹, Shrikant Balkrishna Jagtap^2*, Rahul Ramchandra Jadhav³, Jyoti Prafulla Jadhav³.

DOI : http://dx.doi.org/10.13005/ojc/380203

The complexes of M(Db-scdtc)2 type [ Cu(Db-scdtc)2, Ni(Db-scdtc)2, and Zn(Db-scdtc)2] were synthesized by reaction of S-p-chlorobenzyl-β-N-(4-dimethylaminophenyl)methylenedithiocarbazate (H-Db-scdtc) and metal acetate salts in which Db-scdtc is anionic form of S-p-chlorobenzyl-β-N-(4-dimethylaminophenyl)methylenedithiocarbazate. The complexes and ligand were characterized by UV-Vis, Infrared spectroscopy, NMR (H1 and C13), elemental analysis and Molar conductance, and Magnetic moment. The Magnetic moment Data suggest that central zinc metal ion in zinc complex forms a four-coordinate tetrahedron with two bidentate Schiff base ligands shows tetrahedral geometry, while copper and nickel complexes exhibited square planar geometry. The biological activity experiment adopted by the well diffusion method. Preliminary studies showed that the dithiocarbazate ligand has a significant inhibitory effect on the proliferation of pathogenic strains compared to the metal complexes. Moreover, in metal complexes Cu2+ complexes showed prominent antibacterial activity against Salmonella typhi and Staphylococcus aureus. In addition, Ni2+ complex exhibited good antifungal activity against Candida albicans.

Antibacterial Activity; Antifungal Activity; Ligand; Metal Complexes; Schiff base

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