ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

p-Toluene-sulfonic Acid-Catalyzed One-pot, Three-component Synthesis of 4-(4-(Piperidin-1-yl)phenyl)-2-Thioxo-1,2,3,4-Tetrahydro-5H-Chromeno[4,3-d]Pyrimidin-5-One

Hamdy Khamees Thabet1*, Mustafa Turki Ubeid1, Mohamed Yousef Abu Shuheil1 and Mohd Imran2

DOI : http://dx.doi.org/10.13005/ojc/380223


Abstract:

Here we communicate a method for the synthesis of 4-(4-(piperidin-1-yl)phenyl)-2-thioxo-1,2,3,4-tetrahydro-5H-chromeno[4,3-d]pyrimidin-5-one in one step. The compound was prepared by reacting 4-hydroxy-coumarin, 4-piperidinobenzaldehye, and thiourea in a catalytic quantity of p-toluenesulfonic acid. The novelty of the compound was checked by Sci-finder. The compound was analyzed by NMR spectroscopy (1H, 13C), and mass spectrometry. The computational studies indicate that the synthesized compound possesses suitable physicochemical properties, drug-likeliness features, and good oral bioavailability.

Keywords:

Chromeno[4,3-d]pyrimidine; Piperidine, p-Toluenesulfonic acid

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