Abstract

Venugopal N. V. S^*and Bujji Reddy K

DOI : http://dx.doi.org/10.13005/ojc/380233

Nowadays fungal diseases certainly affect people with undermined immune system. Fungal infections are most likely impinge on skin, lungs, nails etc and it leads to systemic infection.Voriconazole (VCZ) is an antifungal medication of the triazole class used to treat infections caused by a fungus.VCZ is used to treat patients suffering with invasive fungal infections. The focus of this paper was to study the performance swot of antifungal activity of untreated VCZ and micronized VCZ. Size reduction of drug treated as an imperative operation to make handling of the drug easier, increase surface area per unit volume, and separate entrapped components. The size reduction process may involve accelerating particles so either particle-to-particle impact. Biological evaluation study was conducted by using Aspergillus niger and Candida albicans as test organisms’ .Zone of inhibition was measured to assess antifungal activity by adopting agar diffusion process. The antifungal activity was conducted to the untreated VCZ material having particle size, about 207 microns and micronized VCZ having particle size 12 microns. The determination of size distribution of VCZ particles was examined through Dynamic light scattering (DLS) and Scanning Electron Microscopy (SEM) for treated and untreated VCZ.The structural identification study was conducted by Ultraviolet spectroscopy (UV) and Fourier transform Infrared spectroscopy (FT-IR). The anti fungal activity effectiveness of micronized VCZ illustrates increased efficiency when compared to untreated VCZ material.

Aspergillus niger; Candida albicans; Electron microscopy; Micronization process; Voriconazole

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