Abstract
Synthesis, Characterization and Cytotoxicity of Ni (II), Pd (II), Pt (II) Complexes with 6-Methoxy-2, 3, 4, 5-Tetrahydropyridine (MTP)
Hikmat Ali Mohamad1*
, Widad Taha Al-Kattan2, Zena Mashal Al-Daly2 and Ali Nafia Najim2
DOI : http://dx.doi.org/10.13005/ojc/360515
Abstract:
Reaction of 2 moles of (MTP) with one mole of MCl2 gave colored complexes with general formula; [M(MTP)2Cl2]. [M = Ni+2, Pd+2, and Pt+2]. All synthesized complexes are well-characterized using, FT-IR, 1HNMR, 13NMR, UV-Vis. Spectra furthermore of magnetic susceptibility, CHN analysis, and molar conductivity. The results illustrated that divalent metal ions were coordinated with the ligands through nitrogen atoms in square planar spatial arrangements. The complexes were screened for their cytotoxicity effects versus MCF-7 cell line and showed that [Pt(MTP)2Cl2] complex has good cytotoxicity in comparison with the other complexes.
Keywords:Cisplatin; Cytotoxicity; MCF-7 Cell Line; Metal Complexes
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