Abstract

Rajeev Kumar^1*, Sanjay Kumar² and Madhu Bala³

DOI : http://dx.doi.org/10.13005/ojc/360518

Abstract: The condensation product of isatin with semicarbazide
(IstscabH), thiosemicarbazide (IsttscabH) and thiocarbohydrazide
(BisttcabH) form inclusion complexes with β-cyclodextrin (β-cydx=C42H70O35), in 1:1 molar ratio having composition [β-cydx-IstscabH/IsttscabH] and [(β-cydx-BisttcabH)]. The inclusion complexes have been charactised from the studies of IR, UV, NMR and molecular weight determination.The inclusion products are thermally more stable than β-cyclodextrin (240°C). The IR, UV and NMR spectra of isatin derivatives are affected on forming inclusion complexes with β-cyclodextrin ring. The inclusion products as well as isatin derivatives show ionic nature at room temperature in DMF solution. The antibacterial activity of inclusion products are larger than simple Schiff bases.

β-cyclodextrin; Inclusion Complexes; Isatin Schiff Base; Semicarbazone; Thiocarbohydrazone Antibacterial Screening; Thiosemicarbazone

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