Abstract

Mst. Roksana Khatun^1*, Md. Monirul Islam² and Md. Din Islam¹

DOI : http://dx.doi.org/10.13005/ojc/360510

Molecular interactions and aggregation behavior of cloxacillin sodium (CloNa) in water and aqueous NaCl solutions was studied through volumetric and ultrasonic sound velocity method at 298.15 K and atmospheric pressure. Density, ρ, and ultrasonic sound velocity, u, of cloxacillin sodium in water and aqueous NaCl solutions were measured with a digital density and ultrasonic sound velocity analyzer (DSA 5000, Anton Paar, Austria). And from the investigational data, apparent molar volume,〖 ϕ〗_v, adiabatic compressibility, βS, apparent molar adiabatic compressibility, ϕ_k, limiting apparent molar volume, ϕ_v^0, limiting apparent molar adiabatic compressibility,〖 ϕ〗_k^0 , and aggregation concentration, CMC of cloxacillin sodium was calculated. The outcomes indication exhibits very significant evidence about the interactions among solute-solvent-co-solute (solute-solute, solute-solvent) and aggregation behavior in the aqueous environment and this result would be useful for the drug action in human body with pharmacological applications.

Adiabatic Compressibility; Aggregation; Apparent Molar Adiabatic Compressibility; Apparent Molar Volume; Cloxacillin Sodium; Nacl; Solute-Solute Interactions; Solute-Solvent

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