ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Solid Phase Synthesis of Biologically Active Benzimidazole Derivatives Catalysed by Methanesulphonic Acid-SiO2 under Solvent Free Condition

Arup Dattaaand Sanjay Roya*

DOI : http://dx.doi.org/10.13005/ojc/360325


Abstract:

A simple an expeditious method was established for the synthesis of 2-Substituted-1H-Benzimidazole derivatives at 90ยบ C using o-phenylenediamine and different aldehydes. It has been found that a mixture of Methanesulphonic acid-SiO2 to be an effective catalyst to generate moderate to high yield of a wide variety of 2-substituted benzimidazole derivatives through a simple workup process. Solid phase, rapid reaction, solvent free technique and simplicity of the reaction procedure are the advantages of this protocol.

abstract

Keywords:

Benzimidazole; Heterogeneous Catalyst; Solvent Free Condition; Solid Phase

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