Abstract

Anuradha Rajasekaran^1*, Selvan Abraham², Sasikala Mohanasundaram³ and Pirakathiswaran Gurusamy¹

DOI : http://dx.doi.org/10.13005/ojc/360205

The study reports synthesize of novel Schiff base ligand decorated with pyrazolone moiety using 4-Aminoantipyrine phosphate and 5-Bromosalicylaldehyde. Structural characterization of the synthesized pyrazolone moiety was carried out using 1H-NMR, Mass Spectroscopy, elemental analysis with EDAX, UV-Vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR) and single crystal X-Ray diffraction. Novel Schiff base ligand was tested for its bioefficacy, which showed having the properties like antimicrobial against Escherichia coli (MTCC433), Staphylococcus aureus (MTCC3160), antifungal against Aspergillus niger (MTCC2208) Candida albicans (MTCC3160), antioxidant and anti-inflammatory activities. Cytotoxicity study was carried out on Hep G2 cell lines and Vero cell lines, which revealed the anticancer activity of the Schiff base ligand. Molecular docking interaction of ligand towards enzymes like DNA gyrase of E.coli, S. aureus showed good binding energy. The optimum synthesizing temperature of Schiff base ligand was found to be at 30°C, and the synthesised ligand was found to be biologically effective.

Anti-Cancerous Activity; Bioefficacy; Docking Studies; Hep G2 Cell Line Studies; Schiff base Ligand

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