Abstract

Muhamad Zulfaqar Bacho¹, Mohd Fazli Mohammat², Zurina Shaameri², Agustono Wibowo³, Firdaus Kamarulzaman⁴ and Ahmad Sazali Hamzah^2*

DOI : http://dx.doi.org/10.13005/ojc/360214

A multifaceted approach comprising MCR (multicomponent reaction), amination and stereoselective reduction reactions was used to synthesize new pyrrolidine-based iminosugars. The key step of this strategy involves the contruction of a highly functionalised pyrroldine ring skeleton through MCR approach. Subsequently, amination and reduction reactions to the ring skeleton provide a quick access to new pyrrolidine- based imino sugars. The iminosugars were then tested against alpha glucosidase activity in which one compound (4-((4-methoxyphenyl)amino)pyrrolidin-3-ol), was found to be the most potent at low dosage.

Alpha-Glucosidase; Antidiabetic; Iminosugars; Pyrrolidine

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