Abstract

Sazaul Morshed Sazib¹, Sadia Afroz², Tariqul Islam³, Abdullah Al Ragib^2*,4, Muhammad Zukaul Islam⁵ and Abdullah Al Mahmud⁶

DOI : http://dx.doi.org/10.13005/ojc/360117

A comparative pharmacological study of three different unani medicines are performed, trade named Safi, Musaffi and Hemosaf used for blood purification. In which, different concentration of the syrups were evaluated for its possible membrane stabilizing and antioxidant activity. Gallic acid and ascorbic acid were used as a standard for antioxidant activity. Acetyl salicylic acid (ASA) (0.10 mg/ml) was also used as standard drug for membrane stability. The amount of total phenolic content for Safi, Musaffi and Hemosaf was subsequently 542.2 mg, 444.27 mg and 432.20 mg of GAE/mg of sample solution. DPPH radical scavenging activities of three Samples were increased with the increasing concentration. Maximum inhibition (radical scavenging) 85.96% for Hemosaf was observed at 100 µg/ml concentration with IC50 of 1.91 µg/ml compared to standard (ascorbic acid) inhibition 95.86% with IC50 of 1.93 µg/ml. Among all the syrup fractions, at 8.0 mg/ml concentration maximum effect with a value of 50.24%, 47.70% and 34.85% hindrance of hemolysis of Red Blood Cell (RBC) caused by hypotonic solution of Safi, Musaffi and Hemosaf respectively as compared to 67.01% showed by standard acetyl salicylic acid (ASA). Finally, it might be a source of antioxidant activity and possess good membrane stability effects.

Antioxidant Activity; Membrane Stabilization; Radical Scavenger; Unani Medicine

[ View HTML Full Text]