Abstract

Muazzam Sheriff Maqbul¹, Aejaz A. Khan², Tasneem Mohammed², S. M. Shakeel Iquba^2*, Ibrahim Ahmed Shaikh³, Uday M. Muddapur⁴, Gouse Basha Sheik⁵, S. K. Singh⁶, Mohammed Shahid Hussain⁷ and Mohammed Gamal^8,9

DOI : http://dx.doi.org/10.13005/ojc/360104

This research study aimed at determining the vinyl phenolic compounds with antioxidant properties and antimicrobial activity using acetone and methanol extracts of Saccharomyces cerevisiae (S. cerevisiae) The HPLC-UV technique was employed for the identification of the vinyl phenolic compounds and Ferric and Ferrous reducing anti-oxidant power assay along with radical scavenging methods were applied to determine the anti-oxidant properties of the yeast extract. The biochemical tests showed the presence of alkaloids, reducing sugars, steroid, proteins, phenol, cardiac glycosides and glycosides. Further antimicrobial properties of the yeast extract using Kirby-Bauer disc diffusion method indicates, E.coli exhibits the best susceptibility towards the yeast extract. The antimicrobial susceptibility was excellent for all the isolated uropathogens when compared with the standard antibiotics. The metabolites produced by the yeast exhibits vital pharmaceutical important substances such as analgesic, antipyretic, anti-proliferative and antimicrobial properties. This study is a small attempt towards a larger future to serve the mankind with natural remedies.

Antioxidant Properties, Antimicrobial Activity, Saccharomyces Cerevisiae, Uropathogenic Bacteria, Vinyl Phenolic Compound.

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