ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Synthesis, Spectral Characterization and Antibacterial Activity of Functionalized Hydrazones

D. Kasimbi1, K. Hussain Reddy*1and N. Devanna2

DOI : http://dx.doi.org/10.13005/ojc/350208


Abstract:

New hydrazones have been synthesized by condensing 2-acetylthiophene with acetic hydrazide and benzhydrazide. The synthesized hydrazones viz. 2-acetylthiophene acetoylhydrazone (ATAH), 2-acetylthiophene benzoylhydrazone (ATBH) are characterized in the light of physicochemical and analytical data. Structures of ATAH and ATBH are confirmed by FT-IR, 1H-NMR and Mass spectral data. The hydrazones are screened for their anti-bacterial activities against E Coli, Bacillus cereus, Staphylococcus aureus   and   Pseudomonas aureoginos. Acetoyl hydrazones are found to show more antibacterial activity than the corresponding benzoyl hydrazones.

Keywords:

Antibacterial Action; Characterization; Functionlized Hydrazones; Synthesis

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