Abstract

Garima Prajapat*, Rama Gupta¹ and Narender Bhojak¹

DOI : http://dx.doi.org/10.13005/ojc/350137

Mode of coordination of the drug Sulfanilamide has been meticulously studied in its transition metal complexes with Fe(III), Ni(II) and Cu(II). The present study deals with green synthesis of these metallodrug compounds by microwave irradiation. Elemental, spectral and thermal analysis methods have been carried out for the elucidation of structure of complexes and the coordination behaviour of ligating drug with the metal ions. Sulfanilamide is found to exhibit a bidentate behaviour in Fe(III) and Cu(II) complexes, whereas it shows monodentate coordination with Ni(II). Thermogravimetric data (TGA and DTA) have been utilised to evaluate the kinetic and thermodynamic parameters using Coats and Redfern integral equations. Investigation of antibacterial properties of the complexes has been done against E. coli, S. aureus and B. subtilis.  

Differential Thermogravimetric Analysis (DTA) and Coats and Redfern Equations; Metallodrugs; Microwave Irradiation; Sulfanilamide; Thermogravimetric Analysis (TGA)

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