Abstract

Riyadh J. Nahi* and Zainab I. Kuwait

DOI : http://dx.doi.org/10.13005/ojc/350153

In this present work, a series of new 1-(substituted-phenyl)-1H-1,2,3-triazolyl-4-carboxylic acid derivatives was synthesized via copper (I) catalyzed azide-alkyne cycloaddition reaction. Since these synthesized 1,2,3-triazole compounds containing a carboxyl functional group, it was exploited for the combination of 1,2,3-triazole ring with 1,3,4-oxadiazole ring system in one molecule. Thus, the synthesized 1,2,3-triazoles were the key starting materials to synthesize the target compounds via a condensation reaction with semicarbazide hydrochloride in the presence of POCl₃. Furthermore, the thermal behavior of all newly heterocyclic compounds was also studied by TGA and DTG techniques.

Click Reaction; 1,3-Dipolarcycloaddition; Heterocyclic; 1,3,4-Oxadiazole; 1,2,3-Triazole; Thermal Study

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