Abstract

Muhajirin Dean*¹, Retno Handajani² and Junaidi Khotib³

DOI : http://dx.doi.org/10.13005/ojc/350155

The discovery of antiviral drugs is developing new alternative medication and economics prices. One of the natural resources for alternative medicine is the water extract of faloak stem bark which is a material used by Kupang Community as an antiviral drug. The HCV JFH1 lifecycle inhibition is expressed in IC₅₀ (inhibitory concentration 50%) and the toxicity of water extract of faloak stem bark in hepatocyte cell line Huh7it is expressed in CC₅₀ (cytotoxicity concentration 50%). Determining the results obtained using Microsoft Office^® Excell 2013^®. The water extract of faloak stem bark has an inhibition of HCV genotype 2a strain JFH1 with the IC₅₀ 11.57μg/mL and the toxicity water extract of faloak stem bark in the Huh7it cell line hepatocyte with the CC₅₀ >1000μg/mL. Mode of action activities from water extract of faloak stem bark can be inhibited all step HCV life cycle. The first step is entry step has the inhibition 93.97%, post-entry step has the inhibition 96.75%, and combination step (entry and post-entry step) has the inhibition was 100%. The active compound in the water extract of faloak stem bark was epicatechin 875mg/kg. The water extract of faloak stem bark can be a candidate for antivirals against HCV JFH1.

Faloak; Hepatitis C Virus; Sterculia Quadrifida R.Br

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