Abstract
Triterpenoids from the Bark of Aglaia Glabrata and Their In Vitro Effects on P-388 Murine Leukemia Cells
Desi Harneti1, Asep Supriadin2, Rani Maharani1,3, Nurlelasari1, Tri Mayanti1, Ace Tatang Hidayat1,3, Risyandi Anwar4, Unang Supratman*1,3
, Khalijah Awang5 and Yoshihito Shiono6
DOI : http://dx.doi.org/10.13005/ojc/350114
Abstract:
Four dammarane-type triterpenoids, dammardienon (1), aglaiabbreviatin E (2), dammar-20,25-dien-3b,24-diol (3) and dammar-24-en-3b,20-diol (4) were isolated from methanolic extract of the bark of Aglaia glabrata. The structures of all triterpenoids were elucidated by 1D-, 2D-NMR, and comparison with previously reported data. All triterpenoids were applied into in vitro bioassay against P-388 murine leukemia cell. Dammar-24-en-3b,20-diol (4) has cytotoxic activity with IC50 value of 9.45 mM towards P-388 murine leukemia cell lines.
Keywords:Aglaia Glabrata; Dammarane-Type Triterpenoid; Meliaceae; P-388 Murine Leukemia Cell
Back to TOC
A New Edition of Web of Science
Journal Impact Factor
2022: 0.5
Five Year: 0.8
Journal is Indexed in
Cabells Whitelist
