Abstract

Abhishek Kumar^*, Jennifer Fernandes and Pankaj Kumar

DOI : http://dx.doi.org/10.13005/ojc/300462

A series of novel substituted N-(3-acetyl-2-oxoquinolin-1(2H)-yl)benzamide (AJQC1-AJQC12) have been synthesized upon refluxing 3-acetyl-1-amino-quinolin-2-one and substituted benzoic acid in the presence of dry redistilled pyridine and silicon tetra chloride as coupling agent. 3-acetyl-1-amino-quinolin-2-one (AJQ1-AJQ12) were synthesized from substituted 3-acetyl coumarin upon refluxing with hydrazine hydrate and ethanol. The structures of the final carboxamide derivatives were confirmed by IR, ¹H NMR and mass spectra. The synthesized compounds were screened for their antimicrobial activity by tube dilution method and anti tubercular activity by microplate Alamar blue assay. Most of the compounds have exhibited promising antibacterial, anti fungal and anti tubercular activities.

2-Quinolones; carboxamide; antimicrobial activity; minimum inhibitory concentration; antitubercular activity

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