Abstract

Maria Ulfa¹ and Didik Prasetyoko²

DOI : http://dx.doi.org/10.13005/ojc/340554

The SBA-15 was studied for the first time for ibuprofen loading as anti inflamantory molecule model. The SBA-15 was synthesized from Pluronic P123 as the structure-directing agent and TEOS as the silica source. The framework capacity and structural change of the SBA-15 was investigated by varying the amount loading of ibuprofen inflamantory molecule. The structural properties of the synthesized samples after laoding treatment was analyzed by FTIR, SEM and EDX. The decreasing intensity of the SBA-15 as increasing ibuprofen loading by FTIR measurement demonstrated that a big part of mesoporous pipe has been covered by ibuprofen molecule. Spectra of FTIR also show that increasing ibuprofen molecule was decrease the number of sylanol group of the SBA-15 but increase carbonyl and hydroxyl group. The SEM image show not only the average widht of the micropencil-like structure of SBA-15 close to the (1-2 mµ) and lenght of pipe close to the (30 mµ) but also white coral-like structure from ibuprofen excess. The ibuprofen molecule in ona part were obtained homogeneously dispersed within the pore structure of the SBA-15 but in the other part agglomerated without unformity. The elemental analysis by EDAX showed that the sample containing silica, oxygen,carbon and hydrogen that changed gradually as varying ibuprofen loadig. The result show that the structure of SBA-15 has been stable at the given condition which is afforded a maximum loading ibuprofen up to 10 mol at room temperature. The slow release of ibuprofen/SBA-15 is ascribed to its unique SBA-15 structure which is achieved optimum release up to 67% within 60 min.

Drug Delivery System; Ibuprofen; Loading; Release; SBA-15; Structure

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