Abstract

Sarrah Sattar Jabbar

DOI : http://dx.doi.org/10.13005/ojc/3404041

In search of novel antibacterial agent, a series of new isatin derivatives (3a-d) have been synthesized by condensation isatin (2,3-indolinendione) with piperidine (hexahydropyridine), hydrazine hydrate and Boc-amino acids respectively. Compounds synthesized have been characterized by IR spectroscopy and elemental analysis. In addition, the in vitro antibacterial properties have been tested against E. coli, P. aeruginosa, and Bacillus cereus, S. aureus by employing the well diffusion technique. A majority of the synthesized compounds were showing good antibacterial activity  and from comparisons of the compounds, compound 3d has been determined to be the most active compound.

Antibacterial Activity; Boc-amino Acid Isatin; Carbamate Derivatives; Isatin-3-hydrazine; N-Mannich Base

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