Abstract

Amala Subbiah and  Santhi Sambamoorthy

DOI : http://dx.doi.org/10.13005/ojc/3404039

N-4-Methylphenyl (2,4-dihydroxy acetophenylideneimine) (NMEPDHAPI) complexes of Co(II), Ni(II) and Cu(II)  have been synthesized and characterized. A study on their electrochemical, fluorescence and biological behaviour have also been performed. The complexes have been characterized on account of metal estimation studies, conductance behaviour, magnetic property, IR, UV-visible, EPR(Liquid nitrogen temperature) spectral studies and thermal analysis. The 1:2 metal : ligand complex formation is authenticated from the analytical data. Based on the various studies, the Co(II) complex  has been recommended for octahedral geometry and a square planar geometry has been prompted for  Cu(II) and Ni(II) complexes. The electro chemical property of the complexes have been studied by cyclic voltammetry. The Schiff base and its complexes have been scrutinized against bacterial and fungal pathogens. The complexes have been found to be more active than the Schiff base towards most of the pathogens studied. Invitro cytotoxicity  of the copper complex of NMEPDHAPI has been screened  against breast cancer cell lines (MCF-7). The   IC50   value recommend that the copper complex has notable cytotoxicity against breast cancer cell line (MCF-7).

Antimicrobial; Cyclic Voltammetry; Fluorescence; Schiff base.

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