Abstract

Iqbal Azad¹, Firoj Hassan¹, Mohammad Saquib², Naseem Ahmad¹, Abdul Rahman Khan¹, Abdillah G.Al-Sehemi³ and Malik Nasibullah¹

DOI : http://dx.doi.org/10.13005/ojc/340401

Nitrogen containing heterocyclic compounds are biologically significant molecules. This is especially true for pyrrole a five membered nitrogen containing aromatic molecule, which is present as a key structural motif in a large number of drugs and lead molecules. This review aims to provide an overview of the multi-component reaction (MCR) based methodologies used for the synthesis of pyrrole and its derivatives, focusing particularly on eco-friendly methods that avoid the use of hazardous reagents, solvents and catalysts are deemed especially relevant to the disciplines of medicinal chemistry and drug discovery.

Green Chemistry; Heterocyclic Compounds; Medicinal Chemistry; Multi-Component Reaction (MCR); Pyrrole

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