Abstract

Hikmat Ali Mohamad

DOI : http://dx.doi.org/10.13005/ojc/3404027

The one-pot synthesis reaction of one mole MCl₂.nH₂O, where M= Co(II), Ni(II), Mn(II) ,with one mole of 1,5-diphenylthiocarbazone (dithizone;H₂dz), of 1,1-bis(diphenyl phosphine)ferrocene (dppf) and 1,2-bis(diphenyl phosphine) ethane (dppe) gave colored complexes of; [Co(Hdz)(k²-dppf)]Cl, [Ni(Hdz)(k²-dppf)]Cl, [Ni(Hdz)(k²-dppe)]Cl and [Mn(Hdz)(k²-dppf)]Cl. The synthesized complexes have been identified by using ¹HNMR, IR, UV-Vis spectroscopy, micro elemental analysis and molar conductance. All complexes were tested for their anticancer activities on Human breast cancer cell line CAL5. The results showed that [Ni(Hdz)(k²-dppe)]Cl and[Mn(Hdz)(k²-dppf)]Cl have a highest activities than cisplatin in compared to; [Co(Hdz)(k^2-dppf)]Cl, [Ni(Hdz)(k²-dppf)]Cl.

Anticancer Activity; Cobalt; Dithizone; Manganese Complexes; Nickel; Tertiarydiphosphines

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