Abstract

Behrooz Afarideh^1,4, Masoumeh Rajabibazl^1,2, Meisam Omidi³, Bahram Yaghmaee¹, Azam Rahimpour², Reza Khodabakhshi⁴ and Saeeideh Sarvarian⁴

DOI : http://dx.doi.org/10.13005/ojc/3404038

Cancer is one of the greatest health challenges in the world. Every year, many people die because of cancer. Chemotherapy is one of the treatment options in cancer disease. Fluorouracil )5-FU( is one of the chemotherapy dr0075gs, but it has relatively low toxic effect on tumor cells when it is used on free form, which also results in its poor efficacy. GO (graphene oxide) has a single-atomic layer and has several functional groups such as epoxide, carbonyl, carboxyl and hydroxyl which makes it a suitable carrier for drug loading. In the present study, we loaded 5-FU on GO nanocarrier to produce GO/5-FU, and characterized it by FT-IR. CT26 Ds-Red adenocarcinoma cell line was treated with GO/5-FU, free 5-FU, GO, and PBS (Phosphate buffer saline). The results showed significant inhibition of the CT26 Ds-Red cells using GO/5-FU compared to free 5-FU (P<0.05). Therefore, loaded 5-FU on GO (GO/5-FU) could be a new approach for optimization of 5-FU tumor cytotoxicity.

CT26 Ds-Red; Graphene Oxide; 5-FU

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