Abstract

Mariyam^1,2 and Siska Oktapianti²

DOI : http://dx.doi.org/10.13005/ojc/340346

Novel 1-[(1-Phenyl-1H-tetrazol-5-ylimino)-methyl]-naphthalen-2-ol (PTMN) ligand, [Cu(PTMN)ClH2O] and [Co(PTMN)ClH2O] complexes have been synthesized. Characterization of the obtained compounds were performed by 1H-NMR, FT-IR, UV-Vis, Mass spectrometry and thermo-analytical study. The morphology of compounds were determined by SEM, while EDX study was employed to identify elements in ligand and the metal complexes. Metal-ligand compositions were analyzed spectrophotometrically using Job’s continuous-variation method. pH-metric technique was carried out to give the quantity of dissociable protons and protonation sites in the obtained compound. The ligand [Cu(PTMN)ClH2O] and [Co(PTMN)ClH2O] complexes were tested for in vitro antimicrobial properties against YEPDA, Gram-positive and negative bacteria. It was observed that metal complexes showed enhanced antimicrobial potential as compared to the free ligand. In addition, [Cu(PTMN)ClH2O] complex indicated greater antimicrobial activity against most of microbial strains as compared to the ligand and [Co(PTMN)ClH2O] complex.

Antimicrobial Activity; Co(II) Complexes; Cu(II); Electronic Spectra; Synthesis; Tetrazole

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