Abstract

R. Nandhikumar^1,2 and K. Subramani^1,3

DOI : http://dx.doi.org/10.13005/ojc/340328

Synthesis and characterization of N-(phenyl (thiomorpholino) methyl) acetamide (TBA), N-(phenyl (thiomorpholino) methyl) benzamide (TBB), N-(phenyl (thiomorpholino) methyl) nicotinamide (TBN) and 1-N-(phenyl (thiomorpholino) methyl) carbamide (TBC). The synthesized complexes have been characterized by elemental analysis, TLC, IR, ¹H-NMR, ¹³C-NMR and Mass Spectroscopy. The final compounds were tested anti-microbial culture study. In the antibacterial and anti-fungal study the compounds 1-N-(phenyl (thiomorpholino) methyl) carbamide (TBC)  shows very good activity against Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli and N-(phenyl (thiomorpholino) methyl) acetamide (TBA) shows very good activity against Penicillium species, Candida albicans and Aspergillus Niger, compare to other Mannich bases. Small reaction time, eco-friendly products, high yield and very good microbial activity are the main advantages of this procedure which makes it more economical than the other conventional methods.

Antibacterial; Antifungal; Mannich Base; Microwave

[ View HTML Full Text]