Abstract

Pravin Tatyaram Tryambake

DOI : http://dx.doi.org/10.13005/ojc/340360

An efficient, simple one pot, two step procedure has been developed for the synthesis of 2-arylidenehydrazinyl-4-arylthiazole. The reaction of aromatic aldehyde, thiosemicarbazide and phenacyl bromide gave the desired products in good yield. The first reaction product thiosemicarbazone was obtained on reaction with aromatic aldehyde and thiosemicarbazide; without isolating this directly treated with phenacyl bromide in presence of acidic buffer at room temperature desired product was obtained with simple workup procedure.

Thiosemicarbazone; Phenacyl Bromide; Thiazole; Synthesis; One Pot

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