Abstract

Sahar Rihan Fadheland Nidhal Meteab Khamees

DOI : http://dx.doi.org/10.13005/ojc/340354

A study aimed to recommend spectrophotometric method for the determination of clonazepam (CLZ.) in pure form and their pharmaceutical tablets by the reaction of sited drug with ferric chloride in presence potassium ferric cyanide in acid medium to form prussian blue complex and determine it by UV-VIS spectrophotometric at 526 nm. The variables that affect the completion of reaction have been carefully optimized. The linearity range was (2-35 μg.mL^-1) with a molar absorptivity of 3.4200×10⁴ L.mol^-1.cm^-1.  The limit of detection was 0.5703 μg.mL^-1 and Sandell’s sensitivity value was 0.0103μg.cm^-2. The suggest method was successfully used to estimate clonazepam in commercial formulations.

Clonazepam; Prussian blue; ferric chloride; potassium ferric cyanide; spectrophotometry

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