Abstract

Sivagami Swaminathan and Ingarsal Namasivayam

DOI : http://dx.doi.org/10.13005/ojc/340222

An efficient synthesis of 2-Cyanoimino-4-aryl-6-(1,1’-biphenyl-4-yl)-3,4-dihydro-1H-pyrimidines from stryl-4-biphenylketones and cyanoguanidine in presence of  sodium  hydroxide has been described. Cyanoguanidine serves as N-C≡N source for the construction of desired cyanoiminopyrimidines. The structural assignments of the titled products were done accordingly to their spectra like Mass, FT-IR, Proton and Carbon-13 NMR spectroscopy. The more stable tautomeric form was ascertained using Computational frequency analysis. The tested microorganism profile of compounds exhibits significant antimicrobial activity.

Synthesis; 1-(1,1'-Biphenyl-4-yl)ethanone; Chalcone; Cyanoguanidine Cyanoiminopyrimidine; Microbial screening

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