ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Synthesis and Characterization of all Possible Diastereoisomers of Alvimopan

Beeravalli Ramalinga Reddy1,2, Manoj Kumar Dubey1, Ch. Venkata Ramana Reddy2 and Rakeshwar Bandichhor1

DOI : http://dx.doi.org/10.13005/ojc/340246


Abstract:

Isolation of all possible diastereomers of alvimopan 1 was found to be challenging. In order to perform cut off studies during analytical method development, it was mandatory to synthesize and characterize all the diastereomeric impurities. Here in, our efforts toward the synthesis and isolation of alvimopan (1) diastereomers are discussed.

Keywords:

Alvimopan; Diastereomers; Resolution; Antagonists

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