Abstract

Arumugam Ramdass¹, Veerasamy Sathish² and Pounraj Thanasekaran³

DOI : http://dx.doi.org/10.13005/ojc/340101

The use of phosphorogenic heavy-metal complexes has emerged as an attractive platform for luminescence sensing and cellular imaging studies as a result of several merits including precisely arranging the coordination structures and charge-transfer characteristics. This review intends to provide the design principles and the applications of amino acids sensing based on heavy-metal complexes such as Re(I)-, Ru(II)-, Ir(III)-, and Pt(II). These metal complexes function as phosphorogenic sensors with superior activities and selectivities towards amino acids by utilizing several mechanisms, including luminescent responses of “switch-on”. Furthermore, the practical utility of long lifetime and cell permeability of these metal complexes allows to detect luminescence imaging of amino acids in living cells without interference from endogenous fluorophores.

Amino Acids; Cell Imaging; Heavy Metal Complexes; Phosphorescence; Selectivity

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