Abstract

Aseel Faeq Ghaidan¹, Fadhil Lafta Faraj² and Zaynab Saad Abdulghany²

DOI : http://dx.doi.org/10.13005/ojc/340119

Series of new compounds of indole Schiff base derivatives have been synthesized by reaction of 2-(5-Chloro-3,3-dimethyl-1,3-dihydro-indol-2-ylidene)-malonaldehyde with aniline substituted. The chemical structures of the synthesized compounds were characterized by TLC, FT-IR, ¹H, ¹³C NMR and APT ¹³C NMR. The in vitro anticancer activity of the new synthesized compounds tested against – AMJ breast cancer cell line. The revealed data showed that compounds have promising anticancer activity against AMJ13 cell line at low concentrations.

Schiff Bases; Aniline Substituted; Aldehyde; Cytotoxic Activity

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