Abstract

Rafika Indah Paramita¹, Ade Arsianti¹ and Maksum Radji²

DOI : http://dx.doi.org/10.13005/ojc/340132

Gallic acid is a compound that found in many plants, fruits, and foods where the anti-cancer activity is the best activity. However, gallic acid has a problem on the high polarity and low bioavailability. So, it takes molecular modifications in order to increase its lipophilicity, which is expected to increase bioavailability and cytotoxic activity of gallic acid. Hexyl esters derivatives of gallic acid were synthesized and characterized by spectrometer 1H-NMR, 13C-NMR, mass spectrometry and infrared spectrophotometer (FTIR). All compounds were then evaluated for cytotoxic activity on MCF-7 cell line using MTT method. Compound cis-2’-hexenyl-3,4,5-trimethoxygallate (19) had the lowest IC50 value compared with gallic acid and other derivatives hexyl esters. IC50 value of cis-2’-hexenyl-3,4,5-trimethoxygallate (19) is 14.48 µg/ml. Compound (19) also has approached with IC50 values ​​​​of gossypol as a positive control. Compound (19) is a potential compound to inhibit growth of MCF-7 cell line.

Gallic Acid; MCF-7; cytotoxicity Assay; Synthesis of Hexyl Esters Gallate Derivative

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