Abstract

Ravi Kumar G.M.V.N.A.R and Thangamani Arumugam

DOI : http://dx.doi.org/10.13005/ojc/340150

The present work reports a simple and efficient method for the sulfenylation of a wide variety of indoles with aryl, benzothiazolethiols using manganese(III) acetate promoted free radical reaction. This method is selective at the C3 position of indoles and offers several advantages such as broad substrate scope, functional group tolerance (bromo, carboxylic acid, methoxy, difluoromethoxy, ester groups) and gives the required products in good to excellent yields. The experimental simplicity makes it a useful and attractive approach for the synthesis of 3-aryl sulfenyl indoles.  The compounds 1-12 are evaluated for the anti-bacterial agents. Most of them exhibited promising activities.

Sulfenylation of Indoles; Regioselectivity; Manganese(III) Acetate; C-S Bond Formation; Antibacterial Activity

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