ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Eco-friendly Access to β-ketoamides: One-step Catalyst-and Solvent-free Amidation of β-ketoesters Under Microwave Irradiation

Khadidja Dechira1,2, Assya Taleb1, Aouicha Benmaati1, Salih Hacini1 and Hadjira Habib Zahmani1

DOI : http://dx.doi.org/10.13005/ojc/340117


Abstract:

A highly efficient and facile catalyst- and solvent-free one step amidation of β-ketoesters, without using any additional reagents, is described. Therefore, β-ketoamides are obtained in good to excellent yields by condensation of β-ketoesters with various primary or secondary amines. This eco-friendly protocol has been developed under microwave irradiation.

Keywords:

Amidation; β-ketoesters; β-ketoamides; catalyst-free; solvent-free; Microwave irradiation

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