Abstract
Study of A Mercury Complex of an Oral Antidiabetic Drug, Tolbutamide
S. A. Iqbal and S. M. Khan
Abstract:
Tolbutamide, (trade, Restinon) forms 2:1 complex with mercuric acetate in alcoholic medium as indicated by conductometric titrations and Job's method of continuous variation. Structure assigned to the complex is supported by analytical data and infra-red spectroscopy. Preliminary pharmacological studies conducted on a dog revealed that metal complex of this drug is more potent than the parent drug.
Keywords:Mercury; Tolbutamide,; Antidiabetic
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