Abstract

Suresh C. Sharma

6,6-Dimethyl-10a, 11- etheno-10-hydroxy-6H-indolo [1,2-C] [1,3] benzoxazine was synthesised by starting from hydroquinone. The latter was methylated and then subjected to succinoylation, clemmensen's reduction and cyclization to produce 5,8—dimethoxy—1—keto—1,2,3,4—tetraphydra* naphthalene, which on Fischer indole synthesis with phenylhydrazine afforded 1,4—dimethoxy 5,6— dihydrobenyo [a] carbazole, this on aromarization, dimethylation and treatment with acetone in presence of p — toluene sulphonyl chloride afforded the title compound. The structures were elucidated by elemental and IR spectral analysis. The compound secreened for antibacterial activity against E. coli and S. aureus and for antifungal activity against H. sativum and A. alternate. The toxicity was tested on white mice.

Antibacterial; Antifungal; Logical Activities.

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